Why are autosomal dominant disorders rare

Products and services. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information. Please try again. Something went wrong on our side, please try again. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.

IMG Home Autosomal dominant inheritance pattern. Legal Conditions and Terms Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.

Advertising Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Advertising and sponsorship policy Advertising and sponsorship opportunities. Reprint Permissions A single copy of these materials may be reprinted for noncommercial personal use only. Late Effects of Childhood Cancer Treatment. Pediatric Supportive Care. Rare Cancers of Childhood Treatment. Childhood Cancer Genomics. Study Findings.

Metastatic Cancer Research. Intramural Research. Extramural Research. Cancer Research Workforce. Partners in Cancer Research. What Are Cancer Research Studies. Research Studies. Get Involved. Cancer Biology Research. Cancer Genomics Research. Research on Causes of Cancer. Cancer Prevention Research. Cancer Treatment Research. Cancer Health Disparities. Childhood Cancers Research. Global Cancer Research.

Cancer Research Infrastructure. Clinical Trials. Frederick National Laboratory for Cancer Research. Bioinformatics, Big Data, and Cancer. Annual Report to the Nation. Research Advances by Cancer Type. Stories of Discovery.

Milestones in Cancer Research and Discovery. Biomedical Citizen Science. Director's Message. Budget Proposal. Stories of Cancer Research. Driving Discovery. Highlighted Scientific Opportunities. Research Grants. Research Funding Opportunities. Cancer Grand Challenges. Research Program Contacts. Funding Strategy. Grants Policies and Process. Introduction to Grants Process.

This happens even when the matching gene from the other parent is normal. The abnormal gene dominates. This disease can also occur as a new condition in a child when neither parent has the abnormal gene. This is true for each pregnancy. It means that each child's risk for the disease does not depend on whether their sibling has the disease.

If someone is diagnosed with an autosomal dominant disease, their parents should also be tested for the abnormal gene. Examples of autosomal dominant disorders include Marfan syndrome and neurofibromatosis type 1.

Patterns of single-gene inheritance. Philadelphia, PA: Elsevier; chap 7. Scott DA, Lee B.